Ethyl propanimidoate → HCID 178512693, compound

HRID 280739Notes

Reaction equation

HRID 280739 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10](NN)=[O:11])[N:9]=1)[C:2]([NH2:4])=[NH:3].C(=N)([O:17]CC)CC.Cl.C(=N)(OCC)CC>C(O)C>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]([OH:11])=[O:17])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

5

Reactant 3

HCID 11240515Ethyl propanimidoateHCID 13000588Ethyl propanecarboximidate hydrochlorideHCID 178512692HCID 178512692, compound

Product 1

HCID 178512693HCID 178512693, compoundYield 103.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.90 g (14.48 mmol) of 2-guanidino-4-thiazole carboxylic acid hydrazide in 50 ml dry ethanol was slurried with 29.1 mmol of ethyl propionimidate (prepared from 4.0 g (29.1 mmol) of ethyl propionimidate hydrochloride) for 5 days at 25° . The slurry was filtered and the resulting solid was dried for 2 hours at 60° in vacuo to give 2.802 g (75%) of 2-guanidino-4-thiazole carboxylic acid 2-propioniminohydrazide.

Workup

  1. filtrationThe slurry was filtered
  2. customthe resulting solid was dried for 2 hours at 60° in vacuo

Sources & evidence

ORD record
ord-63885d4a6b59426a9e7417f9acbe37bc
Source dataset
uspto-grants-1986_05
Patent number
US04590299

Reaction notes

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