L-Lysine → HCID 13503370, compound

HRID 280777Notes

Reaction equation

HRID 280777 reaction equation
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[CH2:11]([P:18]([NH:27][C@H:28]([C:30]([N:32]1[CH2:46][CH2:45][CH2:44][C@H:33]1[C:34]([N:36]1[CH2:43][CH2:42][CH2:41][C@H:37]1[C:38]([OH:40])=[O:39])=[O:35])=[O:31])[CH3:29])([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:19])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>O>[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[CH2:11]([P:18]([NH:27][C@H:28]([C:30]([N:32]1[CH2:46][CH2:45][CH2:44][C@H:33]1[C:34]([N:36]1[CH2:43][CH2:42][CH2:41][C@H:37]1[C:38]([OH:40])=[O:39])=[O:35])=[O:31])[CH3:29])([CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:19])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 5962L-LysineHCID 13503349HCID 13503349, compound

Product 1

HCID 13503370HCID 13503370, compoundYield 107.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

L-lysine (701 mg, 4.8 m mole) was added to the oily dibenzylphosphoryl-L-alanyl-L-prolyl-L-proline (2.72 g, 5 m mole), and water (40 ml) was added thereto to dissolve the solid substances, and the solution was freeze-dried to obtain an amorphous powder of dibenzylphosphoryl-L-alanyl-L-prolyl-L-proline L-lysine salt (3.4 g).

Workup

  1. additionwas added
  2. dissolutionto dissolve the solid substances
  3. customthe solution was freeze-dried

Sources & evidence

ORD record
ord-dfd07f1bacee4322bd2ac566c6f909e9
Source dataset
uspto-grants-1986_05
Patent number
US04590178

Reaction notes

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