HCID 70039995, compound → HCID 54079365, compound

HRID 280778Notes

Reaction equation

HRID 280778 reaction equation
C([O:8][C:9](=[O:26])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:25])[C@H:16]([CH3:24])[NH:17][P:18]([CH2:22][CH3:23])([CH2:20][CH3:21])=[O:19])C1C=CC=CC=1>CO.[C].[Pd]>[CH2:20]([P:18]([NH:17][C@H:16]([C:15]([N:11]1[CH2:12][CH2:13][CH2:14][C@H:10]1[C:9]([OH:26])=[O:8])=[O:25])[CH3:24])([CH2:22][CH3:23])=[O:19])[CH3:21]

Participants

4

Reactant 1

HCID 70039995HCID 70039995, compound

Product 1

HCID 54079365HCID 54079365, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

The oily diethylphosphoryl-L-alanyl-L-proline benzylester (8.5 g, 20.6 m mole) was dissolved in methanol and palladium-carbon (2 g) was added thereto. The reductive reaction was carried out for 3 hours. The catalyst was removed by filtration and the solvent was distilled off under reduced pressure to obtain an oily diethylphosphoryl-L-alanyl-L-proline.

Workup

  1. customThe reductive reaction
  2. customThe catalyst was removed by filtration
  3. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-0f40261bab984866bb9a2c0854505a14
Source dataset
uspto-grants-1986_05
Patent number
US04590178

Reaction notes

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