Sodium Hydroxide → HCID 70039904, compound

Participants

Reaction Steps

Dibenzylphosphoryl-L-alanyl-N-(2-indanyl)glycyl-L-proline methylester (0.79 g, 1.2 m mole) was dissolved in acetone (5 ml), and sodium hydroxide (0.15 g, 3.8 m mole) in water (4 ml) solution was added thereto while cooling in the ice bath. The mixture was stirred for 1 hour. To this solution water (100 ml) was added, and thereafter this thus formed solution was washed with ethyl ether (50 ml). the ether washed solution was neutralized with 1N hydrochloric acid, and therefrom the desired product was extracted with ethyl acetate. The thus extracted solution was dried with anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain an oily dibenzylphosphoryl-L-alanyl-N-(2-indanyl)glycyl-L-proline (0.77 g, yield: 99.7%).

Provenance & Evidence