HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[alpha-(2,4-Ditert.-pentylphenoxy)-butyroyl]-6-benzyloxy-7-nitro-1,4-benzoxazine-3-one → 4-[alpha-(2,4-Ditert.-pentylphenoxy)-butyroyl]6-hydroxy-7-amino-1,4-benzoxazine-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[alpha-(2,4-Ditert.-pentylphenoxy)-butyroyl]-6-benzyloxy-7-nitro-1,4-benzoxazine-3-one | HCID 21298680 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[alpha-(2,4-Ditert.-pentylphenoxy)-butyroyl]6-hydroxy-7-amino-1,4-benzoxazine-3-one | HCID 21298675 | — |
Reaction Steps
The nitro compound ((f), 8.19 g, 0.0136 mole) in THF (ml 100) was reduced and debenzylated under 25 PSI hydrogen pressure at room temperature in the presence of 10% Pd on charcoal. The resulting amine (g) was not isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04591548 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-d97cdec9131746768808e575906fc92f |
| Source note | uspto-grants-1986_05 |