2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 13371253, compound

Participants

Reaction Steps

30 g of 1α,7α-dimethyl-4-androstene-3,17-dione is heated under reflux in 700 ml of dioxane with 30 g of dichlorodicyanobenzoquinone for 8 hours. After cooling, the product is suctioned off from undissolved matter, washed with dioxane, and the filtrate concentrated under vacuum. The residue is chromatographed on silica gel and recrystallized from acetone/hexane, thus obtaining 18 g of 1,7α-dimethylandrosta-1,4-diene-3,17-dione, mp 148°-151° C.

Provenance & Evidence