Methanol → HCID 13371257, compound

Participants

Reaction Steps

2.2 g of 1-acetoxymethylandrosta-1,4-diene-3,17-dione is stirred under argon gas atmosphere in 20 ml of methylene chloride and 25 ml of methanol with 250 mg of potassium hydroxide at 0° to 5° C. for 5 hours. The mixture is then neutralized with acetic acid, concentration, and precipitated into water. The product is suctioned off, washed with water, and dried. Recrystallization from acetone/hexane yields 1.7 g of 1-hydroxymethylandrosta-1,4-diene-3,17-dione, mp 201°-202° C.

Provenance & Evidence