Sodium Hydroxide → HCID 178432636, compound

Participants

Reaction Steps

2-Guanidino-4-(2-methyl-4-imidazolyl)thiazole monohydrobromide (360.7 g, 1.19 mole; U.S. Pat. No. 4,374,843) was slurried in 7500 ml H2O for 15 minutes at 19° C. With stirring, the pH was slowly adjusted from 5.8 to a stable value of 9.5 with 10% NaOH, 500% 5 ml being required. After stirring a further 0.5 hours, title product was recovered by filtration on sintered glass. The sticky cake was washed with 2000 ml H2O, pulled to a tight cake and finally washed with 1000 ml of hexane. After air drying on the funnel for 18 hours, the entire still-partially-wet cake was taken into the next step.

Provenance & Evidence