Methanesulfonyl chloride → HCID 23320188, compound

Participants

Reaction Steps

To a solution of 1-(3-aminobenzyl)-4-benzhydrylpiperazine (1.43 g) in a mixture of pyridine (3.2 g) and chloroform (20 ml) was dropwise added methanesulfonylchloride (0.31 ml) at 5° to 6° C. with stirring. The mixture was stirred at the same temperature for 30 minutes and at ambient temperature for 2 hours. The reaction mixture was concentrated and the resultant was extracted with ethyl acetate. The extract was washed with water, dried and evaporated in vacuo to give a residue. According to a conventional manner, the residue was converted to fumarate, which was recrystallized from ethanol to afford 1-(3-methanesulfonylaminobenzyl)-4-benzhydrylpiperazine fumarate (0.65 g) as yellow crystals. mp: 213°-215° C.

Provenance & Evidence