HRID280939

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)[C@@H](CCCCCCN1C(=O)c2ccccc2C1=O)N[C@H]1COc2ccccc2N(CC(=O)OC(C)(C)C)C1=O

HCID13622563

未命名化合物

HCID21866389

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)[C@@H](CCCCCCN1C(=O)c2ccccc2C1=O)N[C@H]1COc2ccccc2N(CC(=O)O)C1=O.Cl

HCID70425520

未命名化合物

PROCEDURE

实验过程

In 5 ml of 5N hydrogen chloride-ethyl acetate solution is dissolved 0.12 g of tert-butyl 3(S)-[1(R)-ethoxycarbonyl-7-phthalimidoheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate obtained in Example 64, and the solution is allowed to stand at room temperature for 3 hours. Petroleum ether (100 ml) is added to the solution and the deposited precipitate is dried under reduced pressure to give 0.08 g of 3(S)-[1(R)-ethoxycarbonyl-7-phthalimidoheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride as a colorless powder.

WORKUP

后处理

customthe deposited precipitate is dried under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1cdebd48d484426f93015901b0149030
来源数据集: uspto-grants-1986_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04591458
来源说明: uspto-grants-1986_05

反应 SMILES

[CH2:1]([O:3][C:4]([C@H:6]([NH:24][C@@H:25]1[C:31](=[O:32])[N:30]([CH2:33][C:34]([O:36]C(C)(C)C)=[O:35])[C:29]2[CH:41]=[CH:42][CH:43]=[CH:44][C:28]=2[O:27][CH2:26]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]2[C:14]1=[O:23])=[O:5])[CH3:2].C(OCC)(=O)C.[ClH:51]>>[ClH:51].[CH2:1]([O:3][C:4]([C@H:6]([NH:24][C@@H:25]1[C:31](=[O:32])[N:30]([CH2:33][C:34]([OH:36])=[O:35])[C:29]2[CH:41]=[CH:42][CH:43]=[CH:44][C:28]=2[O:27][CH2:26]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]2[C:14]1=[O:23])=[O:5])[CH3:2]