HCID 13622562, compound → HCID 70046918, compound

HRID 280940Notes

Reaction equation

HRID 280940 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]([NH:24][C@@H:25]1[C:31](=[O:32])[N:30]([CH2:33][C:34]([O:36]C(C)(C)C)=[O:35])[C:29]2[CH:41]=[CH:42][CH:43]=[CH:44][C:28]=2[O:27][CH2:26]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]2[C:14]1=[O:23])=[O:5])[CH3:2].C(OCC)(=O)C.[ClH:51]>>[ClH:51].[CH2:1]([O:3][C:4]([C@@H:6]([NH:24][C@@H:25]1[C:31](=[O:32])[N:30]([CH2:33][C:34]([OH:36])=[O:35])[C:29]2[CH:41]=[CH:42][CH:43]=[CH:44][C:28]=2[O:27][CH2:26]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]2[C:14]1=[O:23])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 13622562HCID 13622562, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 70046918HCID 70046918, compound

Procedure

In 5 ml of 5N hydrogen chloride-ethyl acetate solution is dissolved 0.11 g of tert-butyl 3(S)-[1(S)-ethoxycarbonyl-7-phthalimidoheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate obtained in Example 64, and the solution is allowed to stand at room temperature for 3 hours. Petroleum ether (100 ml) is added to the solution and the deposited precipitate is dried under reduced pressure to give 0.095 g of 3(S)-[1(S)-ethoxycarbonyl-7-phthalimidoheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride as a colorless powder.

Workup

  1. customthe deposited precipitate is dried under reduced pressure

Sources & evidence

ORD record
ord-eff86fa12bef48779d8d71893d16c5cc
Source dataset
uspto-grants-1986_05
Patent number
US04591458

Reaction notes

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