HCID 13622586, compound → HCID 13622609, compound

HRID 280942Notes

Reaction equation

HRID 280942 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C@H:15]([NH:21][C@@H:22]1[C:28](=[O:29])[N:27]([CH2:30][C:31]([O:33]C(C)(C)C)=[O:32])[C:26]2[CH:38]=[CH:39][CH:40]=[CH:41][C:25]=2[O:24][CH2:23]1)[C:16]([O:18][CH2:19][CH3:20])=[O:17])=O)(C)(C)C.C(OCC)(=O)C.[ClH:48]>>[ClH:48].[ClH:48].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C@H:15]([NH:21][C@@H:22]1[C:28](=[O:29])[N:27]([CH2:30][C:31]([OH:33])=[O:32])[C:26]2[CH:38]=[CH:39][CH:40]=[CH:41][C:25]=2[O:24][CH2:23]1)[C:16]([O:18][CH2:19][CH3:20])=[O:17]

Participants

3

Reactant 2

HCID 13622586HCID 13622586, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 13622609HCID 13622609, compound

Procedure

In 10 ml of 5N hydrogen chloride-ethyl acetate solution is dissolved 1.1 g of tert-butyl 3(S)-[7-tert-butoxycarbonylamino-1(S)-ethoxycarbonylheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate obtained in Example 67 and the solution is allowed to stand at room temperature for 3 hours. Petroleum ether (100 ml) is added to the solution and the deposited precipitate is dried under reduced pressure to give 0.9 g of 3(S)-[7-amino-1(S)-ethoxycarbonylheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid dihydrochloride as a colorless powder.

Workup

  1. customthe deposited precipitate is dried under reduced pressure

Sources & evidence

ORD record
ord-58aab8537d814504a06cbbfab29d716a
Source dataset
uspto-grants-1986_05
Patent number
US04591458

Reaction notes

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