HCID 13622559, compound → HCID 70044594, compound

HRID 280945Notes

Reaction equation

HRID 280945 reaction equation
C(OCC)(=O)C.[ClH:7].[CH2:8]([O:10][C:11]([C@@H:13]([NH:30][C@@H:31]1[C:37](=[O:38])[N:36]([CH2:39][C:40]([O:42]C(C)(C)C)=[O:41])[C:35]2[CH:47]=[CH:48][CH:49]=[CH:50][C:34]=2[O:33][CH2:32]1)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]1[C:23](=[O:24])[C:22]2=[CH:25][CH:26]=[CH:27][CH:28]=[C:21]2[C:20]1=[O:29])=[O:12])[CH3:9]>>[ClH:7].[CH2:8]([O:10][C:11]([C@@H:13]([NH:30][C@@H:31]1[C:37](=[O:38])[N:36]([CH2:39][C:40]([OH:42])=[O:41])[C:35]2[CH:47]=[CH:48][CH:49]=[CH:50][C:34]=2[O:33][CH2:32]1)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]1[C:20](=[O:29])[C:21]2=[CH:28][CH:27]=[CH:26][CH:25]=[C:22]2[C:23]1=[O:24])=[O:12])[CH3:9]

Participants

3

Reactant 2

HCID 13622559HCID 13622559, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 70044594HCID 70044594, compound

Procedure

A mixture of 5N hydrogen chloride-ethyl acetate solution (5 ml) and tert-butyl 3(S)-[1(S)-ethoxycarbonyl-6-phthalimidohexyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate (0.1 g) is allowed to stand at room temperature for 3 hours. The mixture is diluted with petroleum ether (80 ml) to precipitate colorless powder, which is collected and dried in vacuo to give 3(S)-[1(S)-ethoxycarbonyl-6-phthalimidohexyl]amino-4oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride (0.08 g).

Workup

  1. customto precipitate colorless powder, which
  2. customis collected
  3. customdried in vacuo

Sources & evidence

ORD record
ord-c7ea6fe5beb546b2bf6941fa1124ac05
Source dataset
uspto-grants-1986_05
Patent number
US04591458

Reaction notes

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