HCID 13622565, compound → HCID 70045341, compound

HRID 280949Notes

Reaction equation

HRID 280949 reaction equation
C(OCC)(=O)C.[ClH:7].[CH2:8]([O:10][C:11]([C@@H:13]([NH:32][C@@H:33]1[C:39](=[O:40])[N:38]([CH2:41][C:42]([O:44]C(C)(C)C)=[O:43])[C:37]2[CH:49]=[CH:50][CH:51]=[CH:52][C:36]=2[O:35][CH2:34]1)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N:21]1[C:25](=[O:26])[C:24]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:23]2[C:22]1=[O:31])=[O:12])[CH3:9]>>[ClH:7].[CH2:8]([O:10][C:11]([C@@H:13]([NH:32][C@@H:33]1[C:39](=[O:40])[N:38]([CH2:41][C:42]([OH:44])=[O:43])[C:37]2[CH:49]=[CH:50][CH:51]=[CH:52][C:36]=2[O:35][CH2:34]1)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N:21]1[C:25](=[O:26])[C:24]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:23]2[C:22]1=[O:31])=[O:12])[CH3:9]

Participants

3

Reactant 2

HCID 13622565HCID 13622565, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 70045341HCID 70045341, compound

Procedure

A mixture of 5N hydrogen chloride-ehtyl acetate solution (5 ml) and tert-butyl 3(S)-[1(S)-ethoxycarbonyl-8-phthalimidooctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate (0.1 g) is allowed to stand at room temperature for 3 hours. The mixture is diluted with petroleum ether (80 ml) to precipitate colorless powder, which is collected and dried in vacuo to give 3(S)-[1(S)-ethoxycarbonyl-8-phthalimidooctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid.hydrochloride (0.067 g).

Workup

  1. customto precipitate colorless powder, which
  2. customis collected
  3. customdried in vacuo

Sources & evidence

ORD record
ord-f0f193e465a942699600efbdbf9e49e6
Source dataset
uspto-grants-1986_05
Patent number
US04591458

Reaction notes

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