HCID 13622568, compound → HCID 70045099, compound

HRID 280954Notes

Reaction equation

HRID 280954 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]([NH:26][C@@H:27]1[C:33](=[O:34])[N:32]([CH2:35][C:36]([O:38]C(C)(C)C)=[O:37])[C:31]2[CH:43]=[CH:44][CH:45]=[CH:46][C:30]=2[O:29][CH2:28]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]1[C:19](=[O:20])[C:18]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:17]2[C:16]1=[O:25])=[O:5])[CH3:2].C(OCC)(=O)C.[ClH:53]>>[ClH:53].[CH2:1]([O:3][C:4]([C@@H:6]([NH:26][C@@H:27]1[C:33](=[O:34])[N:32]([CH2:35][C:36]([OH:38])=[O:37])[C:31]2[CH:43]=[CH:44][CH:45]=[CH:46][C:30]=2[O:29][CH2:28]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]1[C:19](=[O:20])[C:18]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:17]2[C:16]1=[O:25])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 13622568HCID 13622568, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 70045099HCID 70045099, compound

Procedure

A mixture of tert-butyl 3(S)-[1(S)-ethoxycarbonyl-9-phthalimidononyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate (0.08 g) and 5N hydrogen chloride-ethyl acetate solution (5 ml) is allowed to stand at room temperature for 3 hours. The mixture is diluted with petroleum ether (80 ml) to precipitate colorless powder, which is collected and dried under reduced pressure to yield 3(S)-[1(S)-ethoxycarbonyl-9-phthalimidononyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride (0.066 g).

Workup

  1. customto precipitate colorless powder, which
  2. customis collected
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-e667c8203f1347d7aa4a46dee10d9c40
Source dataset
uspto-grants-1986_05
Patent number
US04591458

Reaction notes

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