HCID 13622590, compound → HCID 13622615, compound

HRID 280956Notes

Reaction equation

HRID 280956 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C@H:17]([NH:23][C@@H:24]1[C:30](=[O:31])[N:29]([CH2:32][C:33]([O:35]C(C)(C)C)=[O:34])[C:28]2[CH:40]=[CH:41][CH:42]=[CH:43][C:27]=2[O:26][CH2:25]1)[C:18]([O:20][CH2:21][CH3:22])=[O:19])=O)(C)(C)C.C(OCC)(=O)C.[ClH:50]>>[ClH:50].[ClH:50].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C@H:17]([NH:23][C@@H:24]1[C:30](=[O:31])[N:29]([CH2:32][C:33]([OH:35])=[O:34])[C:28]2[CH:40]=[CH:41][CH:42]=[CH:43][C:27]=2[O:26][CH2:25]1)[C:18]([O:20][CH2:21][CH3:22])=[O:19]

Participants

3

Reactant 2

HCID 13622590HCID 13622590, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 13622615HCID 13622615, compound

Procedure

A mixture of tert-butyl 3(S)-[9-tert-butoxycarbonylamino-1(S)-ethoxycarbonylnonyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate (0.33 g) and 5N hydrogen chloride-ethyl acetate solution (8 ml) is allowed to stand for 2.5 hours at room temperature. The mixture is diluted with petroleum ether (80 ml) to deposit colorless powder, which is collected and dried under reduced pressure to give 3(S)-[9-amino-1(S)-ethoxycarbonylnonyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid dihydrochloride (0.25 g).

Workup

  1. customis collected
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-a86b940e6ae14e08a084b18ae6042c45
Source dataset
uspto-grants-1986_05
Patent number
US04591458

Reaction notes

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