Dimethylformamide → HCID 20143719, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-(1-benzyloxycarbonyl-4-piperidyl)heptanoic acid (6.4 g), sodium bicarbonate (3.1 g) and ethyl iodide (8.6 g) and N,N-dimethylformamide (20 ml) is stirred for 3 hours at 100° C. After further addition of ethyl iodide (2.9 g) and sodium bicarbonate (1 g), the stirring is continued for further 2.5 hours at 100° C. After cooling, the mixture is diluted with water (200 ml) and extracted with ethyl acetate (300 ml). The extract is washed successively with water, 0.1N hydrochloric acid and sodium bicarbonate solution, dried over anhydrous magnesium sulfate and evaporated in vacuo to give ethyl 7-(1-benzyloxycarbonyl-4-piperidyl)heptanoate (5 g) as an oil.

Provenance & Evidence