4-(Bromomethyl)-1-fluoro-2-phenoxybenzene → HCID 23338837, compound
Reaction equation
[C:1]1([S:7][CH:8]2[CH:10]([C:11]([OH:13])=[O:12])[C:9]2([Cl:15])[Cl:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:16][C:17]1[CH:22]=[CH:21][C:20]([S:23][CH:24]2[CH:26]([C:27]([OH:29])=[O:28])[C:25]2([F:31])[F:30])=[CH:19][CH:18]=1.[CH2:32]([S:37][CH:38]1[CH:40]([C:41]([OH:43])=[O:42])[C:39]1([CH3:45])[CH3:44])[CH2:33][CH2:34][CH2:35][CH3:36].[F:46][C:47]1[CH:54]=[CH:53][C:50]([CH2:51]Br)=[CH:49][C:48]=1[O:55][C:56]1[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=1>>[C:1]1([S:7][CH:8]2[CH:10]([C:11]([O:13][CH2:51][C:50]3[CH:53]=[CH:54][C:47]([F:46])=[C:48]([O:55][C:56]4[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=4)[CH:49]=3)=[O:12])[C:9]2([Cl:15])[Cl:14])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1.[F:16][C:17]1[CH:18]=[CH:19][C:20]([S:23][CH:24]2[CH:26]([C:27]([O:29][CH2:51][C:50]3[CH:53]=[CH:54][C:47]([F:46])=[C:48]([O:55][C:56]4[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=4)[CH:49]=3)=[O:28])[C:25]2([F:31])[F:30])=[CH:21][CH:22]=1.[CH2:32]([S:37][CH:38]1[CH:40]([C:41]([O:43][CH2:51][C:50]2[CH:53]=[CH:54][C:47]([F:46])=[C:48]([O:55][C:56]3[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=3)[CH:49]=2)=[O:42])[C:39]1([CH3:44])[CH3:45])[CH2:33][CH2:34][CH2:35][CH3:36]Participants
7
Reactant 4
Product 3
Procedure
Each of the acids, 3-phenylthio-2,2-dichlorocyclopropanecarboxylic acid, 3-(4-fluorophenylthio)-2,2-difluorocyclopropane carboxylic acid, and 3-(n-pentylthio)-2,2-dimethylcyclopropanecarboxylic acid is reacted with 4-fluoro-3-phenoxybenzyl bromide using the procedure of Example 3 to yield 4-fluoro-3-phenoxybenzyl 3-phenylthio-2,2-dichlorocyclopropanecarboxylate, 4-fluoro-3-phenoxybenzyl 3-(4-fluorophenylthio)-2,2-difluorocyclopropanecarboxylate and 4-fluoro-3-phenoxybenzyl 3-(n-pentylthio)-2,2-dimethylcyclopropanecarboxylate, respectively.
Sources & evidence
- ORD record
- ord-43d8b45b9e794f93a7d7af9b427a5d96
- Source dataset
- uspto-grants-1980_09
- Patent number
- US04225533
Reaction notes
Loading…