Acetone → Beclomethasone dipropionate n-hexane

HRID 28105Notes

Reaction equation

HRID 28105 reaction equation
[CH3:1][CH2:2][C:3]([O:5][CH2:6][C:7]([C@:9]1([O:32][C:33]([CH2:35][CH3:36])=[O:34])[C@@:13]2([CH3:30])[CH2:14][C@H:15]([OH:29])[C@:16]3([Cl:28])[C@:26]4([CH3:27])[C:20](=[CH:21][C:22]([CH:24]=[CH:25]4)=[O:23])[CH2:19][CH2:18][C@H:17]3[C@@H:12]2[CH2:11][C@@H:10]1[CH3:31])=[O:8])=[O:4].C(Cl)Cl.CC(C)=O>CCCCCC>[CH3:1][CH2:2][C:3]([O:5][CH2:6][C:7]([C@:9]1([O:32][C:33]([CH2:35][CH3:36])=[O:34])[C@@:13]2([CH3:30])[CH2:14][C@H:15]([OH:29])[C@:16]3([Cl:28])[C@:26]4([CH3:27])[C:20](=[CH:21][C:22]([CH:24]=[CH:25]4)=[O:23])[CH2:19][CH2:18][C@H:17]3[C@@H:12]2[CH2:11][C@@H:10]1[CH3:31])=[O:8])=[O:4].[CH3:6][CH2:7][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

5

Reactant 3

HCID 180AcetoneHCID 6344DichloromethaneHCID 21700Beclomethasone Dipropionate

Product 1

HCID 70194159Beclomethasone dipropionate n-hexane

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

The beclomethasone dipropionate-n-hexane solvate is prepared by dissolving the beclomethasone dipropionate in a suitable organic solvent, such as methylene chloride or acetone, and then adding n-hexane to this solution resulting in the formation of a precipitate. The precipitate is filtered and dried to afford the beclomethasone dipropionate-n-hexane solvate.

Workup

  1. customThe beclomethasone dipropionate-n-hexane solvate is prepared
  2. filtrationThe precipitate is filtered
  3. customdried

Sources & evidence

ORD record
ord-a88205c2903543be866b25bf4d868ba8
Source dataset
uspto-grants-1980_09
Patent number
US04225597

Reaction notes

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