HRID28105

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID180

Acetone

C3H6O

HCID6344

Dichloromethane

CH2Cl2

结构：CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C

HCID21700

Beclazone

C28H37ClO7

PRODUCTS

生成物

结构：CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C.CCCCCC

HCID70194159

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8058

n-Hexane

C6H14

PROCEDURE

实验过程

The beclomethasone dipropionate-n-hexane solvate is prepared by dissolving the beclomethasone dipropionate in a suitable organic solvent, such as methylene chloride or acetone, and then adding n-hexane to this solution resulting in the formation of a precipitate. The precipitate is filtered and dried to afford the beclomethasone dipropionate-n-hexane solvate.

WORKUP

后处理

customThe beclomethasone dipropionate-n-hexane solvate is prepared
filtrationThe precipitate is filtered
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a88205c2903543be866b25bf4d868ba8
来源数据集: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04225597
来源说明: uspto-grants-1980_09

反应 SMILES

[CH3:1][CH2:2][C:3]([O:5][CH2:6][C:7]([C@:9]1([O:32][C:33]([CH2:35][CH3:36])=[O:34])[C@@:13]2([CH3:30])[CH2:14][C@H:15]([OH:29])[C@:16]3([Cl:28])[C@:26]4([CH3:27])[C:20](=[CH:21][C:22]([CH:24]=[CH:25]4)=[O:23])[CH2:19][CH2:18][C@H:17]3[C@@H:12]2[CH2:11][C@@H:10]1[CH3:31])=[O:8])=[O:4].C(Cl)Cl.CC(C)=O>CCCCCC>[CH3:1][CH2:2][C:3]([O:5][CH2:6][C:7]([C@:9]1([O:32][C:33]([CH2:35][CH3:36])=[O:34])[C@@:13]2([CH3:30])[CH2:14][C@H:15]([OH:29])[C@:16]3([Cl:28])[C@:26]4([CH3:27])[C:20](=[CH:21][C:22]([CH:24]=[CH:25]4)=[O:23])[CH2:19][CH2:18][C@H:17]3[C@@H:12]2[CH2:11][C@@H:10]1[CH3:31])=[O:8])=[O:4].[CH3:6][CH2:7][CH2:9][CH2:10][CH2:11][CH3:12]