反应详情

温度

60 °C

11.45 g (0.05 mol) of 3,5-bis-trifluoromethylaniline were dissolved in 80 ml of dry toluene, and 6.7 g (0.05 mol) of β-chloropropionyl isocyanate in 20 ml of dry toluene were added. The mixture was stirred at 60° C. for 1 hour, the solvent was distilled off in vacuo and the residue was taken up in petroleum ether. The crystalline product was filtered off and dried. 14.5 g (80.5% of theory) of N-(3,5-bis-trifluoromethyl-phenyl)-N'-(β-chloropropionyl)-urea, which melts at 175° C., were obtained.

1. distillationthe solvent was distilled off in vacuo
2. filtrationThe crystalline product was filtered off
3. customdried