HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenol → 1-Methyl-2-(2-p-chlorophenoxyethyl)-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenol | HCID 4684 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(2-Chloroethyl)-1-methylpiperidine | HCID 3016566 | — |
| Catalyst | Benzyl triethylammonium chloride | HCID 66133 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Methyl-2-(2-p-chlorophenoxyethyl)-piperidine | HCID 23339173 | — |
Reaction Steps
200 ml of 50% aqueous sodium hydroxide solution and 1 g of triethylbenzylammonium chloride are added to a solution of 12.8 g of p-chlorophenol in 100 ml of CH2Cl2 ; 16.2 g of 1-methyl-2-(2-chloroethyl)-piperidine are added dropwise, while stirring; and the reaction mixture is stirred for a further one hour. After customary working up, 1-methyl-2-(2-p-chlorophenoxyethyl)-piperidine is obtained. Hydrochloride, m.p. 139°-140°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04225608 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-2812348ef1c64c43accd809c79458783 |
| Source note | uspto-grants-1980_09 |