反应详情

23.5 g of 1,3-dimethyl-4-p-hydroxyphenoxy-hexahydroazepine are dissolved in 100 ml of absolute ethanol, 200 ml of 0.5 N ethanolic KOH are added, the reaction mixture is stirred for one hour at 20° and evaporated and the residue is taken up in 250 ml of absolute DMF. 12.6 g of dimethyl sulfate are added in portions, while stirring. The mixture is boiled for 2 hours and evaporated and the residue is worked up in the customary manner, giving 1,3-dimethyl-4-p-methoxyphenoxy-hexahydroazepine, 2 oily isomers, Rf 0.36 and 0.55.

1. customevaporated
2. addition12.6 g of dimethyl sulfate are added in portions
3. stirringwhile stirring
4. waitThe mixture is boiled for 2 hours
5. customevaporated