HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → Ethyl 4-[(4-chlorophenyl)imino]-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | Ethyl 4-oxo-1-piperidinecarboxylate | HCID 34767 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 4-[(4-chlorophenyl)imino]-1-piperidinecarboxylate | HCID 14665236 | — |
Reaction Steps
A mixture of 171.2 parts of ethyl 4-oxo-1-piperidinecarboxylate, 159.5 parts of 4-chlorobenzenamine, 1520 parts of anhydrous methylbenzene and a few crystals of 4-methylbenzenesulfonic acid is stirred and refluxed for 7 hours. (The reaction vessel is provided with a reflux-condensor and water-separator). The methylbenzene is evaporated and the oily residue is distilled in vacuo, yielding 192 parts of oily ethyl 4-[(4-chlorophenyl)imino]-1-piperidinecarboxylate; bp. 171°-176° C. at 0.4 mm. pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04225606 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-69afb760ce334456b0c8437bc4ff6a35 |
| Source note | uspto-grants-1980_09 |