反应详情

To a stirred solution of 8 parts of ethyl 4-[(2,6-dimethylphenyl)amino]-1-piperidinecarboxylate in 4 parts of pyridine and 80 parts of benzene are added dropwise 7.7 parts of benzeneacetyl chloride in 40 parts of benzene. After the addition is complete, the whole is heated to reflux and stirred at reflux temperature for 3h.45. The reaction mixture is cooled and filtered. The benzene-phase is washed with water and then with sodium hydrogen carbonate solution and with water. After evaporation, an oily residue is obtained, which solidifies on triturating in 1,1'-oxybisethane, to yield 5 parts of ethyl 4-[N-(2,6-dimethylphenyl)-N-(phenylacetyl)amino]-1-piperidinecarboxylate; mp. 106° C.

1. additionAfter the addition
2. temperaturethe whole is heated
3. temperatureto reflux
4. temperatureat reflux temperature for 3h.45
5. temperatureThe reaction mixture is cooled
6. filtrationfiltered
7. washThe benzene-phase is washed with water
8. customAfter evaporation
9. customan oily residue is obtained
10. customon triturating in 1,1'-oxybisethane