反应详情

To a stirred and warm (40° C.) solution of 12 parts of potassium hydroxide in 200 parts of 2-propanol are added at once 21 parts of ethyl 4-{N-(4-chlorophenyl)-N-[(3-methoxyphenyl)acetyl]-amino}-1-piperidinecarboxylate and the whole is stirred and refluxed for 17 hours. The reaction mixture is cooled, filtered and evaporated. The semi-solid residue is acidified with a diluted hydrochloric acid solution, washed with 1,1'-oxybisethane and the aqueous acid phase is alkalized with sodium hydroxide solution. The free base is extracted with trichloromethane. The extract is dried and evaporated. The residue is crystallized from a mixture of 1,1'-oxybisethane and hexane, yielding 7.8 parts of N-(4-chlorophenyl)-3-methoxy-N-(4-piperidinyl)benzeneacetamide; mp. 85.7° C.

1. stirringthe whole is stirred
2. temperaturerefluxed for 17 hours
3. temperatureThe reaction mixture is cooled
4. filtrationfiltered
5. customevaporated
6. washwashed with 1,1'-oxybisethane
7. extractionThe free base is extracted with trichloromethane
8. customThe extract is dried
9. customevaporated
10. customThe residue is crystallized from a mixture of 1,1'-oxybisethane and hexane