Toluene → t-Butyl 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-1-piperidinecarboxylate

HRID 281749Notes

Reaction equation

HRID 281749 reaction equation
[C:33]([CH:34]=[P:35]([CH2:36][CH2:37][CH2:38][CH3:39])([CH2:40][CH2:41][CH2:42][CH3:43])[CH2:44][CH2:45][CH2:46][CH3:47])#[N:48].[CH3:49][c:50]1[cH:51][cH:52][cH:53][cH:54][cH:55]1.[CH3:56][CH2:57][O:58][CH2:59][CH3:60].[Cl:1][c:2]1[cH:3][cH:4][c:5]([S:8](=[O:9])(=[O:10])[CH:11]([CH2:12][CH2:13][N:14]([C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:22][CH2:23][OH:24])[c:25]2[c:26]([F:32])[cH:27][cH:28][c:29]([F:31])[cH:30]2)[cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([S:8](=[O:9])(=[O:10])[C:11]2([c:25]3[c:26]([F:32])[cH:27][cH:28][c:29]([F:31])[cH:30]3)[CH2:12][CH2:13][N:14]([C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:22][CH2:23]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 3283Diethyl EtherHCID 4622928CyanomethylenetributylphosphoraneHCID 59750811t-Butyl N-[3-[(4-chlorophenyl)sulfonyl]-3-(2,5-difluorophenyl)propyl]-N-(2-hydroxyethyl)carbamate

Product 1

HCID 59750843t-Butyl 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-1-piperidinecarboxylate

Sources & evidence

ORD record
ord-aad819050d074c73bbb5d7e5f4848bcc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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