5-Bromothiophene-2-carboxylic acid → 5-Bromo-thiophene-2-carboxylic acid (4-{2-oxo-2-[4-(2-oxo-2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethyl}-thiazol-2-yl)-amide
Reaction equation
[Br:24][c:25]1[cH:26][cH:27][c:28]([C:30](=[O:31])[OH:32])[s:29]1.[NH2:1][c:2]1[s:3][cH:4][c:5]([CH2:7][C:8](=[O:9])[N:10]2[CH2:11][CH2:12][N:13]([CH2:16][C:17]([N:18]3[CH2:19][CH2:20][CH2:21][CH2:22]3)=[O:23])[CH2:14][CH2:15]2)[n:6]1>>[NH:1]([c:2]1[s:3][cH:4][c:5]([CH2:7][C:8](=[O:9])[N:10]2[CH2:11][CH2:12][N:13]([CH2:16][C:17]([N:18]3[CH2:19][CH2:20][CH2:21][CH2:22]3)=[O:23])[CH2:14][CH2:15]2)[n:6]1)[C:30]([c:28]1[cH:27][cH:26][c:25]([Br:24])[s:29]1)=[O:31]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-9591a68b568842da86d975ca0110620a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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