N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanol → 2-(2,6-difluorophenyl)-4-(3-tert-butylphenyl)-5,6-dihydro(4H)1,3-oxazine

HRID 281901Notes

Reaction equation

HRID 281901 reaction equation
[F:1][c:2]1[c:3]([C:4](=[O:5])[NH:6][CH:7]([CH2:8][CH2:9][OH:10])[c:11]2[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[CH3:20])[cH:14][cH:15][cH:16]2)[c:21]([F:25])[cH:22][cH:23][cH:24]1.[F:26][c:27]1[cH:28][cH:29][cH:30][c:31]([F:32])[c:33]1[C:34]([NH:35][CH:36]([c:37]1[cH:38][cH:39][c:40]([Cl:41])[cH:42][cH:43]1)[CH2:44][CH2:45][OH:46])=[O:47]>>[F:1][c:2]1[c:3]([C:4]2=[N:6][CH:7]([c:11]3[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[CH3:20])[cH:14][cH:15][cH:16]3)[CH2:8][CH2:9][O:10]2)[c:21]([F:25])[cH:22][cH:23][cH:24]1

Participants

3

Reactant 2

HCID 15790732N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanolHCID 22115246N-(2,6-difluorobenzoyl)-3-amino-3-(3-tert-butylphenyl)-1-propanol

Product 1

HCID 221152372-(2,6-difluorophenyl)-4-(3-tert-butylphenyl)-5,6-dihydro(4H)1,3-oxazine

Sources & evidence

ORD record
ord-4f68ecb5bc204dc89026a253cb7f91b2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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