Methanol → 4-(2-{4-[(2,3-Dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]piperidin-1-yl}ethyl)-6-methoxypyrido[2,3-b]pyrazin-3(4H)-one

HRID 282160Notes

Reaction equation

HRID 282160 reaction equation
[C:35]([O:36][BH3-:37])(=[O:38])[CH3:39].[CH3:41][OH:42].[Cl:43][CH2:44][Cl:45].[NH2:1][CH:2]1[CH2:3][CH2:4][N:5]([CH2:8][CH2:9][n:10]2[c:11]3[c:12]([n:13][cH:14][c:15]2=[O:16])[cH:17][cH:18][c:19]([O:21][CH3:22])[n:20]3)[CH2:6][CH2:7]1.[Na+:40].[O:23]1[CH2:24][CH2:25][O:26][c:27]2[cH:28][n:29][c:30]([CH:33]=[O:34])[cH:31][c:32]21>>[NH:1]([CH:2]1[CH2:3][CH2:4][N:5]([CH2:8][CH2:9][n:10]2[c:11]3[c:12]([n:13][cH:14][c:15]2=[O:16])[cH:17][cH:18][c:19]([O:21][CH3:22])[n:20]3)[CH2:6][CH2:7]1)[CH2:33][c:30]1[n:29][cH:28][c:27]2[c:32]([cH:31]1)[O:23][CH2:24][CH2:25][O:26]2

Participants

7

Reactant 6

HCID 887MethanolHCID 923Sodium ionHCID 6344DichloromethaneHCID 12268230AcetoxyborohydrideHCID 218736682,3-Dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehydeHCID 578153944-[2-(4-Aminopiperidin-1-yl)ethyl]-6-methoxypyrido[2,3-b]pyrazin-3(4H)-one

Product 1

HCID 248668674-(2-{4-[(2,3-Dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]piperidin-1-yl}ethyl)-6-methoxypyrido[2,3-b]pyrazin-3(4H)-one

Sources & evidence

ORD record
ord-623cf5dccba14c908b745d2e6996b586
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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