4-Hydroxypyrrolidine → [5-Cyclopropyl-3-methyl-1-[3-(trifluoromethyl)phenyl]pyrazol-4-yl]-[4-(3-hydroxypyrrolidin-1-yl)piperidin-1-yl]methanone

HRID 282186Notes

Reaction equation

HRID 282186 reaction equation
[CH:1]1([c:4]2[c:5]([C:20](=[O:21])[N:22]3[CH2:23][CH2:24][C:25](=[O:28])[CH2:26][CH2:27]3)[c:6]([CH3:19])[n:7][n:8]2-[c:9]2[cH:10][c:11]([C:15]([F:16])([F:17])[F:18])[cH:12][cH:13][cH:14]2)[CH2:2][CH2:3]1.[OH:29][CH:30]1[CH2:31][NH:32][CH2:33][CH2:34]1>>[CH:1]1([c:4]2[c:5]([C:20](=[O:21])[N:22]3[CH2:23][CH2:24][CH:25]([N:32]4[CH2:31][CH:30]([OH:29])[CH2:34][CH2:33]4)[CH2:26][CH2:27]3)[c:6]([CH3:19])[n:7][n:8]2-[c:9]2[cH:10][c:11]([C:15]([F:16])([F:17])[F:18])[cH:12][cH:13][cH:14]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 67314190[5-Cyclopropyl-3-methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbonyl]-piperidin-4-one

Product 1

HCID 67314425[5-Cyclopropyl-3-methyl-1-[3-(trifluoromethyl)phenyl]pyrazol-4-yl]-[4-(3-hydroxypyrrolidin-1-yl)piperidin-1-yl]methanone

Sources & evidence

ORD record
ord-142a7869eead4117af348c476205af5f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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