HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2',4'-Difluoro(1,1'-biphenyl)-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(2',4'-Difluorophenyl)phenylacetate | HCID 23339943 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2',4'-Difluoro(1,1'-biphenyl)-4-ol | HCID 100955 | — |
Reaction Steps
A 30 liter resin pot is fitted with stirrer, thermometer and reflux condenser, and charged with 2.62 kg. of 50% aqueous sodium hydroxide and 11.34 liters of water. 4-(2',4'-Difluorophenyl)phenylacetate (1.876 kg., 7.55 m) is added and the batch is heated to reflux over 2.5 hours. The batch is refluxed for 2 hours (in solution at 75°), then cooled to 100° and added to a solution of 3.27 liters of concentrated hydrochloric acid in 9.8 liters of water in a 50 liter resin pot over a 30 minute period.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04225730 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-dc15e23bc8184272bff1e209a9457cc9 |
| Source note | uspto-grants-1980_09 |