2-Methoxy-1-(piperazin-1-yl)ethan-1-one → 1-[4-[2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-1-yl]-2-methoxyethanone

HRID 282543Notes

Reaction equation

HRID 282543 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([O:33][CH2:34][CH3:35])[c:8]([C:11]2=[N:15][CH:14]([c:16]3[cH:17][cH:18][c:19]([Cl:22])[cH:20][cH:21]3)[CH:13]([c:23]3[cH:24][cH:25][c:26]([Cl:29])[cH:27][cH:28]3)[N:12]2[C:30](=[O:31])[Cl:32])[cH:9][cH:10]1.[CH3:36][O:37][CH2:38][C:39](=[O:40])[N:41]1[CH2:42][CH2:43][NH:44][CH2:45][CH2:46]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([O:33][CH2:34][CH3:35])[c:8]([C:11]2=[N:15][CH:14]([c:16]3[cH:17][cH:18][c:19]([Cl:22])[cH:20][cH:21]3)[CH:13]([c:23]3[cH:24][cH:25][c:26]([Cl:29])[cH:27][cH:28]3)[N:12]2[C:30](=[O:31])[N:44]2[CH2:43][CH2:42][N:41]([C:39]([CH2:38][O:37][CH3:36])=[O:40])[CH2:46][CH2:45]2)[cH:9][cH:10]1

Participants

3

Reactant 2

HCID 137155722-Methoxy-1-(piperazin-1-yl)ethan-1-oneHCID 87323557Racemic-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride

Product 1

HCID 1784662591-[4-[2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-1-yl]-2-methoxyethanone

Sources & evidence

ORD record
ord-aef328b7e32548c5acfd92bb46c64043
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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