反应详情

To an ice cold stirred solution of α-n-octyl-2,4-dichlorobenzyl cyanide (40 g., 0.14 mole) in 250 ml. of pyridine containing a suspension of paraformaldehyde (21 g., 0.7 mole) is added 1 ml. of benzyl triethylammonium hydroxide. The mixture is stirred under nitrogen at room temperature for 72 hours. The reaction mixture is poured into 2 liters of water and extracted with ether. The combined ether extracts are washed with water, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 40 g. of a thick oil.

1. additionis added 1 ml
2. extractionextracted with ether
3. washThe combined ether extracts are washed with water, saturated sodium chloride solution
4. dry with materialdried over magnesium sulfate
5. customThe solvent is evaporated
6. customto give 40 g