Dimethyl Sulfoxide → 1-(4-(1-(hydroxymethyl)cyclopentylamino)-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone

HRID 282740Notes

Reaction equation

HRID 282740 reaction equation
[CH3:42][S:43]([CH3:44])=[O:45].[F:1][C:2]([F:3])([F:4])[S:5]([O:6][c:7]1[c:8]2[c:9]([n:10][c:11]([NH:13][c:14]3[cH:15][cH:16][c:17](-[c:20]4[cH:21][n:22][cH:23][o:24]4)[cH:18][cH:19]3)[n:12]1)[CH2:25][CH2:26][N:27]([C:29]([CH3:30])=[O:31])[CH2:28]2)(=[O:32])=[O:33].[NH2:34][C:35]1([CH2:40][OH:41])[CH2:36][CH2:37][CH2:38][CH2:39]1>>[c:7]1([NH:34][C:35]2([CH2:40][OH:41])[CH2:36][CH2:37][CH2:38][CH2:39]2)[c:8]2[c:9]([n:10][c:11]([NH:13][c:14]3[cH:15][cH:16][c:17](-[c:20]4[cH:21][n:22][cH:23][o:24]4)[cH:18][cH:19]3)[n:12]1)[CH2:25][CH2:26][N:27]([C:29]([CH3:30])=[O:31])[CH2:28]2

Participants

4

Reactant 3

HCID 679Dimethyl SulfoxideHCID 663071-AminocyclopentanemethanolHCID 593337606-Acetyl-2-(4-(oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl trifluoromethanesulfonate

Product 1

HCID 461984821-(4-(1-(hydroxymethyl)cyclopentylamino)-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone

Sources & evidence

ORD record
ord-b07a9cf797164b51b85fdf4dcdfd49e3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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