1-(4-Methoxy-3-methylphenyl)ethan-1-one → (RS)-1-(3-bromo-5-ethoxymethyl-phenyl)-1-(4-methoxy-3-methyl-phenyl)-ethanol

HRID 282794Notes

Reaction equation

HRID 282794 reaction equation
[Br:13][c:14]1[cH:15][c:16]([Br:24])[cH:17][c:18]([CH2:20][O:21][CH2:22][CH3:23])[cH:19]1.[CH2:25]([Li:26])[CH2:27][CH2:28][CH3:29].[CH3:1][O:2][c:3]1[c:4]([CH3:12])[cH:5][c:6]([C:9]([CH3:10])=[O:11])[cH:7][cH:8]1>>[CH3:1][O:2][c:3]1[c:4]([CH3:12])[cH:5][c:6]([C:9]([CH3:10])([OH:11])[c:14]2[cH:15][c:16]([Br:24])[cH:17][c:18]([CH2:20][O:21][CH2:22][CH3:23])[cH:19]2)[cH:7][cH:8]1

Participants

4

Reactant 3

HCID 248061-(4-Methoxy-3-methylphenyl)ethan-1-oneHCID 578250901,3-Dibromo-5-ethoxymethyl-benzeneHCID 178418339Butyllithium

Product 1

HCID 67348902(RS)-1-(3-bromo-5-ethoxymethyl-phenyl)-1-(4-methoxy-3-methyl-phenyl)-ethanol

Sources & evidence

ORD record
ord-dbf08eb482b0462a808cb4948d883fc6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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