Boronic Acid → AZD4694 Precursor

HRID 282924Notes

Reaction equation

HRID 282924 reaction equation
[BH:20]([OH:21])[OH:22].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([N:7]([CH3:8])[c:9]1[n:10][c:11]([N+:16](=[O:17])[O-:18])[c:12]([Br:15])[cH:13][cH:14]1)=[O:19].[CH2:23]([CH3:24])[O:25][CH2:26][O:27][c:28]1[cH:29][cH:30][c:31]2[c:32]([cH:33][cH:34][o:35]2)[cH:36]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([N:7]([CH3:8])[c:9]1[n:10][c:11]([N+:16](=[O:17])[O-:18])[c:12](-[c:34]2[cH:33][c:32]3[c:31]([cH:30][cH:29][c:28]([O:27][CH2:26][O:25][CH2:23][CH3:24])[cH:36]3)[o:35]2)[cH:13][cH:14]1)=[O:19]

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 46183971(5-Bromo-6-nitro-pyridin-2-yl)-methyl-carbamic acid tert-butyl esterHCID 592274505-Ethoxymethoxy-benzofuran

Product 1

HCID 46183972AZD4694 Precursor

Sources & evidence

ORD record
ord-6d31fa553c6a4a53a5fcb45f8d63cc27
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…