(Pyrimidin-5-yl)boronic acid → N-(2-methoxyethyl)-N-methyl-1-((4-morpholino-2-(pyrimidin-5-yl)thieno[2,3-d]pyrimidin-6-yl)methyl)piperidin-4-amine

HRID 282973Notes

Reaction equation

HRID 282973 reaction equation
[Cl:1][c:2]1[n:3][c:4]([N:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[c:5]2[c:6]([n:7]1)[s:8][c:9]([CH2:11][N:12]1[CH2:13][CH2:14][CH:15]([N:18]([CH3:19])[CH2:20][CH2:21][O:22][CH3:23])[CH2:16][CH2:17]1)[cH:10]2.[n:30]1[cH:31][n:32][cH:33][c:34]([B:36]([OH:37])[OH:38])[cH:35]1>>[c:2]1(-[c:34]2[cH:33][n:32][cH:31][n:30][cH:35]2)[n:3][c:4]([N:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[c:5]2[c:6]([n:7]1)[s:8][c:9]([CH2:11][N:12]1[CH2:13][CH2:14][CH:15]([N:18]([CH3:19])[CH2:20][CH2:21][O:22][CH3:23])[CH2:16][CH2:17]1)[cH:10]2

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 866235331-((2-chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)-N-(2-methoxyethyl)-N-methylpiperidin-4-amine

Product 1

HCID 58233892N-(2-methoxyethyl)-N-methyl-1-((4-morpholino-2-(pyrimidin-5-yl)thieno[2,3-d]pyrimidin-6-yl)methyl)piperidin-4-amine

Sources & evidence

ORD record
ord-fcd2499b250745d79ac48e435330fb6c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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