HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 283Generated: October 25, 2026
tert-Butyl piperazine-1-carboxylate → HCID 68248250, compound
https://huagongshe.com/reaction/283
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | Methyl 4-iodosalicylate | HCID 11380407 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | Binap, (A+-)- | HCID 634876 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 68248250 | HCID 68248250 | 0% |
Reaction Steps
tert-butyl piperazine-1-carboxylate (0.670 g, 3.60 mmol) and methyl 2-hydroxy-4-iodobenzoate (1 g, 3.60 mmol), BINAP (0.224 g, 0.36 mmol), cesium carbonate (2.461 g, 7.55 mmol) were put inDME (18 mL), tris(dibenzylideneacetone)dipalladium(0) (0.165 g, 0.18 mmol) was added last. Reaction wsa purged by nitrogen, and heated at90 °C overnight. No desired product was found.
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-50654e3db36e4cb59399fcb1f475b246 |
|---|
| Source note | 750 AstraZeneca ELN dataset |
|---|
