HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 28334Generated: October 28, 2026
Chlorotrimethylsilane → Methyl-4-oxo-4-[4'-(trifluoromethoxy)-1,1'-biphenyl-4-yl]butanoate
https://huagongshe.com/reaction/28334
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2,2-Dimethoxypropane | HCID 6495 | — |
| Reactant | 4-Oxo-4-[4'-(trifluoromethoxy)-1,1'-biphenyl-4-yl]butyric acid | HCID 12056883 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl-4-oxo-4-[4'-(trifluoromethoxy)-1,1'-biphenyl-4-yl]butanoate | HCID 11256659 | — |
Reaction Steps
Crude 4-oxo-4-[4′-(trifluoromethoxy)-1,1′-biphenyl-4-yl]butyric acid (25 g, content: 65%, GC, silylated, 100% method) is dissolved in a mixture of methanol (50 ml) and 2,2-dimethoxypropane (11.5 g, 110 mmol), treated with trimethylsilyl chloride (0.75 g, 7 mmol) and stirred at 50° C. for 16 h. The reaction mixture is then concentrated and the residue is recrystallized from toluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07419936B2 |
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| Source dataset | uspto-grants-2008_09 |
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| ORD ID | ord-94a7ac36b8a0497681810865690b64ae |
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| Source note | uspto-grants-2008_09 |
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