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HRID28340

反应详情

EQUATION

反应方程式

HRID 28340 的结构方程式

REACTANTS

反应物

2
结构：C[O-].[Na+]
HCID10942334

Methanol, sodium salt

CH3NaO

结构：CC(=O)Oc1cc2c(cc1I)[C@H]1CC[C@]3(C)C(=O)CC[C@H]3[C@@H]1[C@@H](OC(C)=O)C2
HCID69105006

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CC[C@@H]3c4cc(I)c(O)cc4C[C@H](O)[C@H]3[C@@H]1CCC2=O
HCID11611293

未命名化合物

收率 68.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

For the removal of both acetyl protective groups, 700 mg (1.4 mmol) of 3,7β-diacetoxy-2-iodo-estra-1,3,5(10)-trien-17-one, dissolved in 20 ml of methanol, was mixed with 200 mg of sodium methanolate, and the solution was stirred overnight. Then, it was mixed with 2.5 g of Amberlite IR-120, stirred for 30 minutes, filtered, and the solution was concentrated by evaporation in a rotary evaporator. Flash chromatography (cyclohexane/ethyl acetate) yielded 396 mg (68%) of colorless crystals.

WORKUP

后处理

  1. additionThen, it was mixed with 2.5 g of Amberlite IR-120
  2. stirringstirred for 30 minutes
  3. filtrationfiltered
  4. concentrationthe solution was concentrated by evaporation in a rotary evaporator