2-Bromo-6-methoxypyridine → N-(1-(4-hydroxy-4-(6-methoxypyridin-2-yl)cyclohexyl)azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide

HRID 283589Notes

Reaction equation

HRID 283589 reaction equation
[Br:17][c:18]1[cH:19][cH:20][cH:21][c:22]([O:23][CH3:24])[n:25]1.[NH:37]1[CH2:38][CH:39]([NH:41][C:42]([CH2:43][NH:44][c:45]2[n:46][cH:47][n:48][c:49]3[cH:50][cH:51][c:52]([C:55]([F:56])([F:57])[F:58])[cH:53][c:54]23)=[O:59])[CH2:40]1.[O:26]1[C:27]2([CH2:28][CH2:29][C:30](=[O:31])[CH2:32][CH2:33]2)[O:34][CH2:35][CH2:36]1.[OH:1][C:2]1([c:9]2[n:10][c:11]([O:15][CH3:16])[cH:12][cH:13][cH:14]2)[CH2:3][CH2:4][C:5](=[O:8])[CH2:6][CH2:7]1>>[OH:1][C:2]1([c:9]2[n:10][c:11]([O:15][CH3:16])[cH:12][cH:13][cH:14]2)[CH2:3][CH2:4][CH:5]([N:37]2[CH2:38][CH:39]([NH:41][C:42]([CH2:43][NH:44][c:45]3[n:46][cH:47][n:48][c:49]4[cH:50][cH:51][c:52]([C:55]([F:56])([F:57])[F:58])[cH:53][c:54]34)=[O:59])[CH2:40]2)[CH2:6][CH2:7]1

Participants

5

Reactant 4

HCID 2568102-Bromo-6-methoxypyridineHCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 593616224-Hydroxy-4-(6-methoxy-pyridin-2-yl)-cyclohexanoneHCID 68003594N-(azetidin-3-yl)-2((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide

Product 1

HCID 68004146N-(1-(4-hydroxy-4-(6-methoxypyridin-2-yl)cyclohexyl)azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide

Sources & evidence

ORD record
ord-b8c111918bf443a989b0a0b09e25c1bf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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