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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 283714Generated: October 26, 2026

1-(4-Amino-3-fluorophenyl)pyrazin-2(1H)-one → 5-chloro-thiophene-2-carboxylic acid {(1RS,2SR,4SR)-4-[2-fluoro-4-(2-oxo-2H-pyrazin-1-yl)-phenylcarbamoyl]-2-hydroxy-cyclopentylmethyl}-amide

https://huagongshe.com/reaction/283714

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-Amino-3-fluorophenyl)pyrazin-2(1H)-oneHCID 23086774—
Reactant(1SR,3RS,4SR)-3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-4-hydroxy-cyclopentanecarboxylic acid methyl esterHCID 68687973—
Product5-chloro-thiophene-2-carboxylic acid {(1RS,2SR,4SR)-4-[2-fluoro-4-(2-oxo-2H-pyrazin-1-yl)-phenylcarbamoyl]-2-hydroxy-cyclopentylmethyl}-amideHCID 73230879—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (8/10)
ORD IDord-396a6744e9454d02b6e0a4b53ef75897
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (8/10)