Sodium ion → tert-butyl N-[1-[4-[2-(2-amino-3-pyridinyl)-5-[3-(2,6-dimethylmorpholin-4-yl)phenyl]imidazo[4,5-b]pyridin-3-yl]phenyl]cyclobutyl]carbamate

HRID 283766Notes

Reaction equation

HRID 283766 reaction equation
[CH3:36][CH:37]1[O:38][CH:39]([CH3:58])[CH2:40][N:41]([c:43]2[cH:44][c:45]([B:49]3[O:50][C:51]([CH3:52])([CH3:53])[C:54]([CH3:55])([CH3:56])[O:57]3)[cH:46][cH:47][cH:48]2)[CH2:42]1.[CH3:61][O:62][CH2:63][CH2:64][O:65][CH3:66].[Cl:67][CH2:68][Cl:69].[NH2:1][c:2]1[n:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]2[c:11]([n:12][c:13]([Cl:16])[cH:14][cH:15]2)[n:17]1-[c:18]1[cH:19][cH:20][c:21]([C:24]2([NH:28][C:29]([O:30][C:31]([CH3:32])([CH3:33])[CH3:34])=[O:35])[CH2:25][CH2:26][CH2:27]2)[cH:22][cH:23]1.[Na+:60].[OH-:59]>>[NH2:1][c:2]1[n:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]2[c:11]([n:12][c:13](-[c:45]3[cH:44][c:43]([N:41]4[CH2:40][CH:39]([CH3:58])[O:38][CH:37]([CH3:36])[CH2:42]4)[cH:48][cH:47][cH:46]3)[cH:14][cH:15]2)[n:17]1-[c:18]1[cH:19][cH:20][c:21]([C:24]2([NH:28][C:29]([O:30][C:31]([CH3:32])([CH3:33])[CH3:34])=[O:35])[CH2:25][CH2:26][CH2:27]2)[cH:22][cH:23]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 961HydroxideHCID 6344DichloromethaneHCID 80711,2-DimethoxyethaneHCID 711383982,6-Dimethyl-4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholineHCID 86675348tert-butyl (1-(4-(2-(2-aminopyridin-3-yl)-5-chloro-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate

Product 1

HCID 71155927tert-butyl N-[1-[4-[2-(2-amino-3-pyridinyl)-5-[3-(2,6-dimethylmorpholin-4-yl)phenyl]imidazo[4,5-b]pyridin-3-yl]phenyl]cyclobutyl]carbamate

Sources & evidence

ORD record
ord-9919bda9b083416fb7512532254823b0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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