Bicarbonate Ion → 5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-(3-oxetanyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Reaction equation
[Br:1][c:2]1[cH:3][n:4]([CH:12]2[CH2:13][O:14][CH2:15]2)[c:5]2[n:6][cH:7][n:8][c:9]([NH2:11])[c:10]12.[CH2:127]1[O:128][CH2:129][CH2:130][O:131][CH2:132]1.[F:16][c:17]1[c:18]([CH2:24][C:25](=[O:26])[N:27]2[CH2:28][CH2:29][c:30]3[cH:31][c:32]([B:36]4[O:37][C:38]([CH3:39])([CH3:40])[C:41]([CH3:42])([CH3:43])[O:44]4)[cH:33][cH:34][c:35]32)[cH:19][c:20]([F:23])[cH:21][cH:22]1.[Na+:49].[O-:45][C:46]([OH:47])=[O:48].[cH:50]1[cH:51][cH:52][c:53]([P:54]([Pd:55]([P:56]([c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)([c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)[c:69]2[cH:70][cH:71][cH:72][cH:73][cH:74]2)([P:75]([c:76]2[cH:77][cH:78][cH:79][cH:80][cH:81]2)([c:82]2[cH:83][cH:84][cH:85][cH:86][cH:87]2)[c:88]2[cH:89][cH:90][cH:91][cH:92][cH:93]2)[P:94]([c:95]2[cH:96][cH:97][cH:98][cH:99][cH:100]2)([c:101]2[cH:102][cH:103][cH:104][cH:105][cH:106]2)[c:107]2[cH:108][cH:109][cH:110][cH:111][cH:112]2)([c:113]2[cH:114][cH:115][cH:116][cH:117][cH:118]2)[c:119]2[cH:120][cH:121][cH:122][cH:123][cH:124]2)[cH:125][cH:126]1>>[c:2]1(-[c:32]2[cH:31][c:30]3[c:35]([cH:34][cH:33]2)[N:27]([C:25]([CH2:24][c:18]2[c:17]([F:16])[cH:22][cH:21][c:20]([F:23])[cH:19]2)=[O:26])[CH2:28][CH2:29]3)[cH:3][n:4]([CH:12]2[CH2:13][O:14][CH2:15]2)[c:5]2[n:6][cH:7][n:8][c:9]([NH2:11])[c:10]12Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-f1f884d1b4c84eb1984b0a5e5c070926
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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