HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → (S)-2-(2,2-Dimethyl-pentyl)-succinic acid 4-tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 5,5-Dimethyl-3-(4-methyl-2-oxo-5-phenyl-oxazolidine-3-carbonyl)-octanoic acid tert-butyl ester | HCID 68853466 | — |
| Product | (S)-2-(2,2-Dimethyl-pentyl)-succinic acid 4-tert-butyl ester | HCID 86589981 | 112.5% |
Reaction Steps
According to example 1, 3.4 g (7.9 mmol) of 5,5-dimethyl-3-(4-methyl-2-oxo-5-phenyl-oxazolidine-3-carbonyl)-octanoic acid tert-butyl ester, 16 mL (12.8 mmol) of 0.8N LiOH and 4.5 mL of 30% H2O2 gave 2.42 g (>100%) of the title compound as an oil. 1HNMR(400 MHz; CDCl3): 0.77-0.82 (m, 9H), 1.14-1.29 (m, 5H), 1.42 (s, 9H), 1.77 (dd, 1H, J=8 Hz, 16 Hz), 2.36 (dd, 1H, J=6 Hz, 16 Hz), 2.59 (dd, 1H, J=8 Hz, 16 Hz), 2.75-2.85 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07419981B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-b77dfbc27ba946a79d924703350a746d |
| Source note | uspto-grants-2008_09 |