N-(2-aminophenyl)-4-((4-(4-(2-(dimethylamino)ethoxy)phenyl)pyrimidin-2-ylamino)methyl)benzamide → N-(2-Amino-phenyl)-4-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-benzamide

HRID 285043Notes

Reaction equation

HRID 285043 reaction equation
[C:67]([O:68][C:69](=[O:70])[NH:73][c:74]1[c:75]([NH:80][C:81]([c:82]2[cH:83][cH:84][c:85]([CH:88]=[C:89]3[C:90](=[O:95])[NH:91][C:92](=[O:94])[S:93]3)[cH:86][cH:87]2)=[O:96])[cH:76][cH:77][cH:78][cH:79]1)([CH3:71])([CH3:72])[CH3:97].[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH:8][C:9](=[O:10])[c:11]1[cH:12][cH:13][c:14]([CH2:15][NH:16][c:17]2[n:18][c:19](-[c:20]3[cH:21][cH:22][c:23]([O:24][CH2:25][CH2:26][N:27]([CH3:28])[CH3:29])[cH:30][cH:31]3)[cH:32][cH:33][n:34]2)[cH:35][cH:36]1.[NH2:37][c:38]1[cH:39][cH:40][cH:41][cH:42][c:43]1[NH:44][C:45]([c:46]1[cH:47][cH:48][c:49]2[n:50][c:51](-[c:52]3[cH:53][cH:54][c:55]([O:56][C:57]([F:58])([F:59])[F:60])[cH:61][cH:62]3)[s:63][c:64]2[cH:65]1)=[O:66]>>[NH2:73][c:74]1[c:75]([NH:80][C:81]([c:82]2[cH:83][cH:84][c:85]([CH:88]=[C:89]3[C:90](=[O:95])[NH:91][C:92](=[O:94])[S:93]3)[cH:86][cH:87]2)=[O:96])[cH:76][cH:77][cH:78][cH:79]1

Participants

4

Reactant 3

HCID 44570974N-(2-aminophenyl)-4-((4-(4-(2-(dimethylamino)ethoxy)phenyl)pyrimidin-2-ylamino)methyl)benzamideHCID 666221852-(4-Trifluoromethoxy-phenyl)-benzothiazole-6-carboxylic acid (2-aminophenyl)-amideHCID 72466473{2-[4-(2,4-Dioxo-thiazolidin-5-ylidenemethyl)-benzoylamino]-phenyl}-carbamic acid tert-butyl ester

Product 1

HCID 72466478N-(2-Amino-phenyl)-4-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-benzamide

Sources & evidence

ORD record
ord-72ff5547e10e49bc93fe6ce8bfd96997
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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