Thionyl Chloride → 5-Chloromethyl-4-cyclopropyl-2-(4-trifluoromethoxy-phenyl)-pyrimidine

HRID 285136Notes

Reaction equation

HRID 285136 reaction equation
[CH:1]1([c:4]2[n:5][c:6](-[c:12]3[cH:13][cH:14][c:15]([O:18][C:19]([F:20])([F:21])[F:22])[cH:16][cH:17]3)[n:7][cH:8][c:9]2[CH2:10][OH:11])[CH2:2][CH2:3]1.[S:23]([Cl:24])([Cl:25])=[O:26]>>[CH:1]1([c:4]2[n:5][c:6](-[c:12]3[cH:13][cH:14][c:15]([O:18][C:19]([F:20])([F:21])[F:22])[cH:16][cH:17]3)[n:7][cH:8][c:9]2[CH2:10][Cl:25])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 21935760[4-Cyclopropyl-2-(4-trifluoromethoxy-phenyl)-pyrimidin-5-yl]-methanol

Product 1

HCID 219356455-Chloromethyl-4-cyclopropyl-2-(4-trifluoromethoxy-phenyl)-pyrimidine

Sources & evidence

ORD record
ord-05e3c0a7997445ab8560a4501ef03a26
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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