HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 1-(3-(Methylamino)piperidin-1-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N-Methylpiperidin-3-amine | HCID 15670691 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(3-(Methylamino)piperidin-1-yl)ethanone | HCID 58035233 | — |
Reaction Steps
1-Acetyl-3-(methylamino)piperidine was prepared from N3—Cbz protected 3-methylamino-piperidine: i) AcCl, i-Pr2NEt, CH2Cl2; ii) H2 (1 atm), 10% Pd/C, EtOH. 1H-NMR (CD3OD): δ (ppm) 4.0 (m, 1H), 3.6 (m, 1H), 3.4-3.2 (m, 2H), 3.0 (m, 1H), 2.6 (s, 3H), 2.1 (s, 3H), 1.8-1.6 (m, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07419989B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-9682a543237649afa896586ebc0ca1c6 |
| Source note | uspto-grants-2008_09 |