反应详情

A mixture of 2,6-dichloro-pyrimidin-4-yl-amine (0.492 g, 3.0 mmol) and 4-chloro-aniline (1.54 g, 12.0 mmol) in dioxane (25 ml) was heated under reflux for 3 hours. After cooled to room temperature, the mixture was filtered. Concentration of the filtrate under reduced pressure provided the crude product which was purified by flash chromatography on silica gel eluting with ethyl acetate-hexane (1:3) to provide 6-chloro-N*2*-(4-chloro-phenyl)-pyrimidine-2,4-diamine (0.32 g, 42% yield) as a white powder.

1. temperaturewas heated
2. temperatureunder reflux for 3 hours
3. filtrationthe mixture was filtered
4. customConcentration of the filtrate under reduced pressure provided the crude product which
5. customwas purified by flash chromatography on silica gel eluting with ethyl acetate-hexane (1:3)