Acetic Acid → Tert-butyl 3-(3,5-dichlorophenyl)pyrrolidine-1-carboxylate

HRID 285679Notes

Reaction equation

HRID 285679 reaction equation
[BH4-:23].[CH3:27][C:28](=[O:29])[OH:30].[Cl:1][c:2]1[cH:3][c:4]([CH:9]2[CH2:10][CH:11]([O:21][CH3:22])[N:12]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:13]2)[cH:5][c:6]([Cl:8])[cH:7]1.[Na+:24].[Na+:26].[OH-:25]>>[Cl:1][c:2]1[cH:3][c:4]([CH:9]2[CH2:10][CH2:11][N:12]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:13]2)[cH:5][c:6]([Cl:8])[cH:7]1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 923Sodium ion2×HCID 961HydroxideHCID 28123BorohydrideHCID 59593456Tert-butyl 4-(3,5-dichlorophenyl)-2-methoxypyrrolidine-1-carboxylate

Product 1

HCID 59593447Tert-butyl 3-(3,5-dichlorophenyl)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-d398a2a5c92e409bb7ba4fe1d74f537c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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